In article <s4c5c7ec.036 at EM.AGR.CA>, EllsT at EM.AGR.CA (Tim Ells) wrote:
> Hi Folks,
>> I was wondering if there was such a thing as an antibiotic reference
> manual or text that describes the specific modes of action of various
> antibiotics as well as resistance mechanisms of bacteria. I know of some
> general medical microbiology texts that give basic descriptions such as:
> broad spectrum; inhibits cell wall synthesis, etc., however I'm looking for
> more detailed info than that. I want to know how it interrupts cell wall
> synthesis or protein synthesis or nucleic acid synthesis etc. Essentially
> the biochemistry and physiology involved. Thanks in advance.
Chemotherapy of Infection by William Pratt is about 20 years old and "hard
to find" but is pretty good for what you want on mode of action, less good
on mechanism of resistance.