In article <35CB18DB.3387 at brandeis.edu>, "publicacces$"@brandeis.edu
>>I am an undergrad at Brandeis U. who is majoring in both chemistry and
>biochemistry. I have recently been given the opportunity to work in an
>organic chem lab, and I'm trying to branistorm a project. One of my
>biggest interests is in the biogenesis of natural products from amino
>acids. Also interested in the chemical evolution of simple molecules
>larger, more compolex biomolecules, the type of chemistry that became
>the first cell. As it is difficult to find something that no one else
>has researched and published, I turn to you, the research scientists
>there, who can probably help me come up with something. Thanks.
>>melenkir at hotmail.com
Proc Natl Acad Sci U S A 1998 Aug 4;95(16):9078-9081
Can ends justify the means?: Telomeres and the mechanisms of replicative
senescence and immortalization in mammalian cells.
Department of Molecular Biology, Cell Biology, and Biochemistry, Brown
University, Providence, RI 02912.
[Record supplied by publisher]
Finite replicative lifespan, or senescence, of mammalian cells in
is a phenomenon that has generated much curiosity since its description.
The obvious significance of senescence to organismal aging and the
development of cancer has engendered a long-lasting and lively debate
its mechanisms. Recent discoveries concerning the phenotypes of
knockout mice, the consequences of telomerase reexpression in somatic
cells, and genes that regulate senescence have provided striking
insights but also have uncovered important new questions. The objective
this review is to reconcile old observations with new molecular details
to focus attention on the key remaining puzzles.
This paper gives some insight into the direction research into telomeres
and telomerase is headed. This research has vast implications for both
human aging and cancer genesis.
If you want to do some meaningful and productive research I strongly
recommend this line of scientific investigation.
If you do decide to follow this research I can provide you with some
groundbreaking reserch projects and possibly also provide the funding.
Thomas Mahoney, Pres.
Lifeline Laboratories, Inc.