Thank you David. Just what I wanted to hear.
Joe
On 15 May 1997, Enigl wrote:
> In article <337A5809.6298D92E at utoronto.ca>, Martin Jugenburg
> <martin.jugenburg at utoronto.ca> writes:
>> >
> >Prion is a regular brain protein that just happens to be modified
> >(glycosylated) in a unique manner.
>> I've seen this error before. It's time I said something to correct the
> misconception, i.e. the _incorrect_ use of the word prion. A prion is the
> _abnormal_ form (PrPsc) NOT the normal form of the glycoprotein PrPc. A
> prion should not be confused with a "regular" brain protein PrPc. The
> prion is a lethal, pathological, infectious agent, protein.
>> Theory: A prion post-translationally combines with the normal protein
> PrPc to form a heterodimer (PrPc/PrPsc) then to a homodimer (PrPsc/PrPsc).
> The gene for the normal protein is on chromosome 20. The toxic form is
> made before PrPc is sialyated within the Golgi apparatus and before entry
> into lysosomes. PrPsc accumulated in the vacuoles and secondary lysosomes
> leading to cell death (highest concentration in the neurons).
>> The function of the normal ( _NON-prion_ ) PrPc is unknown.
>> Davin
>>> Davin C. Enigl, MEAS (Master of Environmental Arts and Sciences), S.P.
> President-Microbiologist
>> Microbiology Consulting, Hazard Analysis and
> Critical Control Points (HACCP), CGMP, and Validations
> for the Food, Cosmetic, Nutritional Supplement, and Pharmaceutical
> Industry
>>enigl at aol.com>http://members.aol.com/enigl/index.html>> May 15, 1997
> 8:05 am PACIFIC
>
