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salmonella mic

nospam dahd dahd at cy-net.net
Mon Jun 9 13:28:59 EST 1997


In article <33924C1A.23FA at CASRDH.HEALTH.nt.gov.au>, Gary Lum <Gary.Lum at CASRDH.HEALTH.nt.gov.au> says:
>
>Tim Williams wrote:
>
>> In article <338D2C54.64DF at CASRDH.HEALTH.nt.gov.au>, Gary Lum <Gary.Lum at C
>> ASRDH.HEALTH.nt.gov.au> writes
>
>> >In Darwin we tend to treat alot of our _Shigella_ cases because many are
>> >also malnourished at the same time.
>
>> >  I report ampicillin (remember amp is better than amox in
>> >_Shigella_), co-trimoxazole and if systemic infection a third generation
>> >cephalosporin.
>
>> I have read a paper linking use of beta lactams in cases of _Shigella
>> dysenteriae_ and EHEC to increased incidence of HUS (Mechanism appears
>> to be increased inflammatory reaction following breakup of bacteria and
>> exposure to more LPS. Increased cytokine then causes up regulation of
>> receptors to shiga toxin). Anybody want to comment on this? - do the
>> benefits of e.g amp outweigh possible risks of HUS ?
>
>Yeah Tim, I've read that before and thought "Damned cytokines...their
>everywhere".  But seriously, we get a crook child, we prefer to treat
>considering the other co-morbidities we see here.
>
>Regards
>
>Gary

Interesting discussion--- I'd appreciate it if you defined HUS: I don't
recognize the term.  It sounds like you are talking about the negative
effects of LPS mediated through cytokines when cells break up and release
endotoxin---but I need some help understanding exactly what HUS is.
Thanks.










>
>--
>******************************************************** 
>Dr Gary Lum
>Director of Microbiology
>Royal Darwin Hospital
>
>Microbiologists do it with culture and sensitivity 
>Meet me at http://www.ozemail.com.au/~glum/index.html
>E-mail me at mailto:glum at ozemail.com.au,gary.lum at nt.gov.au



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