Glen Tamura gtamura at u.washington.edu
Thu Dec 18 19:37:48 EST 1997

Intravenous immune globulin (human) has been tested in pediatric AIDS
patients, and been found to be of modest benefit in reducing opportunistic
infections in moderately to severely immunocompromised children with

Glen Tamura

On 16 Dec 1997, Yersinia wrote:

> John Cherwonogrodzky writes,
>  Cases of the flesh-eating disease (proteolytic streptococci?) are in the 
>  news recently. If the disease hits people with poor immunity, can doses 
> of  Gamma Globulin (collection of antibodies from generally resistant 
> population) 
> prevent the disease?>
> Passive artificial immunization  - the injection of antibodies made by a 
> person who is immune to a disease into a person who is ill with that 
> disease - was a method of treatment used against infectious bacterial 
> diseases in the pre-antibiotic era. While the donor's antibodies reacted 
> successfully with the pathogenic organisms, the recipients often came 
> down with "serum sickness" because they produced antibodies of their own 
> against the antibiodies they had received.  Perhaps it might work in  
> patients who totally lack immune function (or are close to that point) - 
> they probably wouldn't get the serum sickness -  but since antibodies 
> have a limited life span, they might have to continue to receive 
> injections of donor antibodies until the infection was neutralized.
> Good question, this is really interesting. Does anyone out there know if 
> any studies have been done with passive artificial immunization in AIDS 
> patients?
> Infectionately,
> Yersinia.
> "Van der waals with boughs of holly..."

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