John Chalmers wrote:
>Sorry, but new hemophilia mutations will arise spontaneously
>at a low rate (about 1 in 10^6 or 10^7), but as the trait is
>recessive, the number of cases will be low except in inbred families
>such as European royalty.
I don't wish to be picky, but if you look up a geneolgy of Queen Victoria's
progeny, you will not see any inbreeding resulting in haemophilia. As you
can read in any genetics textbook, the Royal haemophilia gene originated in
a mutation in Vikki herself. Three of her children inherited this gene.
The only case of inbreeding in her descendents was when Elizabeth married
Philip. They share a great-great grandmother, Vikki, but there is no
haemophilia in any of either of their grandparents, parents, or progeny.
Inbreeding, although responsible for many ailments in royal blood over the
centuries was not responsible for the spread of haemophilia in royal
families. Their breeding like rabbits did that all by itself.
