beta-lactamase: how to define a new enzyme

Abramo Ottolenghi aottolen at postbox.acs.ohio-state.edu
Wed Jul 24 07:21:14 EST 1996

In article <4t2rkf$dps_001 at du.hku.hk> lksiu at hkucc.hku.hk (lksiu) writes:

>Subject: beta-lactamase: how to define a new enzyme

>I am a postgraduate student. I am working with the beta-lactamase research. 
>Now I have got a problem in naming a beta-lactamase. I have sequenced a lactamase gene.
>I found that there is a point mutation within the lactamse gene encoded region. 
>Amino change form arg to gly was obtained. However, no change of isoelectric focusing 
>point to the parental enzyme was found. Substrate and inhibition profile was also 
>similar to the parental enzyme. Thus, could I call this gene as the parental gene?
>If I cannot call this gene as the parental beta-lactamase then how to name this 
>mutated gene?
>Thanks for helping
>My E.mail : krisiu at hkusua.hku.hk

This is an interesting question..If anyone has an answer, please post it here. 
 I too would like to know.  Thanks  A. Ottolenghi 
(aottolen at magnus.acs.ohio-state.edu)

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