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Antibiotic (Glycopeptide) resistanc

Howard Magadanz 72457.205 at CompuServe.COM
Fri Jul 7 20:51:18 EST 1995

I'm a development chemical engineer working at a bulk 
pharmaceutical plant.  Can anyone help answer this question, how 
important is the treatment of wastes generated in antibiotic 
manufacturing?  If spent fermentation broth and purification 
extracts containing significant amounts of several antibiotics 
and related chemicals that have anti-microbial activity are 
treated in a warm (45 C) activated sludge type micro biological 
waste treatment plant, could this significantly contribute to the 
development of antibiotic resistant pathogenic bacteria outside 
of the plant?  I wouldn't expect pathogenic bacteria to be 
present in the waste treatment plant, but the bacteria that do 
exist in the plant would presumably become resistant to the 
antibiotics produced at the plant.  Is it likely that these 
resistant activated sludge bacteria could transfer their 
resistance to Methicillin-resistant Staphylococcus aureus after 
discharge from the plant? 

Howard Magadanz	

Howard Magadanz	
72457.205 at CompuServe.com

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