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Finding possible N-terminal secretory signal sequences

Peter Rice pmr at sanger.ac.uk
Thu Jan 9 04:38:16 EST 1997


In article <970108162613.ZM12478 at si05.IRCM.UMontreal.CA> duhaimj at IRCM.UMontreal.CA ("SI-Johanne Duhaime") writes:
>   Is there anything in GCG that allow the following:
>   Find possible N-terminal secretory signal sequences and predict the clivage site 
>   between the signal peptide and the mature protein in a protein sequences.
>
>   M Von Heijne wrote a method on that (Nucleic Acids Researchs 14:4683-4690 (1986)

The EGCG (extended GCG) suite of programs includes SIGCLEAVE, which is
exactly what you ask for. SIGCLEAVE was one of the first EGCG programs
to be developed.

EGCG is a suite of programs that extends and complements the GCG package.

EGCG 8.1 works with (and requires) GCG 8.1, and is available from
ftp.sanger.ac.uk in directory pub/pmr/egcg81

EGCG 9.0 is under development (which will of course work with and require
GCG 9.0), and a beta release will be available in a few weeks.

More information soon through my Web page.

--
------------------------------------------------------------------------
Peter Rice                           | Informatics Division,
E-mail: pmr at sanger.ac.uk             | The Sanger Centre,
Tel: (44) 1223 494967                | Wellcome Trust Genome Campus,
Fax: (44) 1223 494919                | Hinxton, Cambridge, CB10 1SA,
URL: http://www.sanger.ac.uk/~pmr/   | England



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