Do we need local databases?

Cornelius Krasel krasel at alf.biochem.mpg.de
Tue Feb 21 08:33:51 EST 1995

Slightly off-topic, but anyways:

risler at cgmvax.cgm.cnrs-gif.fr wrote:
> For years now, I've never been able to understand how people who spent months 
> or years to sequence something can be satisfied with a mere BLAST search 
> performed in 2 seconds.

Very easy: the average bench molecular biologist has never been taught
computational biology (or what you want to call it). Even I, being
very interested in the subject and having attended some courses, would
be unable to do much more (ok, not only a BLAST but also a BLOCKS search,
but that's about it...).

For example, how does the average user find out if his/her protein is
homologous to the so-called pleckstrin domain? The sequence homology
might be that low that BLAST and FASTA don't give hits, it is not
contained yet in PROSITE (AFAIK), so ... (I would try to do a BLAST
with the consensus sequence, but that'll be probably not very successful


/* Cornelius Krasel, Abt. Lohse, Genzentrum, D-82152 Martinsried, Germany  */
/* email: krasel at alf.biochem.mpg.de                 fax: +49 89 8578 3795  */
/* "Science is the game you play with God to find out what His rules are." */

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