Hi, I currently homology modeling several proteins.
[Homology modeling is attempting to get the structure of a protein, by using
the structure of one or more proteins for which the structure has been
determined. There are 2 broad classes of this. In the de novo approach one
tries to get the structure for a protein for which no closely related protein
structures have been solved. This is very brave. In the second, and
humbler approach, one uses the structure of a closely related protein. I
do the second type.]
In my modeling efforts, I want to address the basic question,
"How much can we trust this structure?" To this end I would like to be
able answer these questions;
1.) Have any structures which were modeled, subsequently been solved, and
if so, how did the model structure compare?
2.) Have model structures been used to predict ligands/pharmaceuticals?
3.) What is the current opinion on the use of model structures?
If anyone has any information on the above, please mail me and I
will summarize for the net.
I understand that many people who might be able to answer these
questions may not be able to, due to confidentiality. But I would still
like to hear their opinions, even if no details of their own work can be
provided.
Many Thanks,
Skip
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* Skip Cole * The three graces of a scientist are *
* rcole at ncsa.uiuc.edu * objectivity, clarity and compassion. *
* (217)355-5308 * The greatest of these being compassion. *
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