Postdoc opportunities are available in the Bernfield Lab at Children's
Hospital/Harvard Medical School studying syndecans & glypicans, cell
surface heparan sulfate proteoglycans (HSPGs) that control cell
behaviors during morphogenesis, tissue repair, host defense & energy
balance.
We study the molecular physiology of gene knockout and transgenic mouse
models and compare with that of analogous mutants in Drosophila. Among
the mouse phenotypes are: Abnormal responses of tissues to injury;
resistance of epithelia to carcinoma production by oncogenes;
maturity-onset obesity of hypothalamic origin; faulty host defenses to
microbial pathogens; abnormal leukocyte-endothelial cell interactions; a
phenocopy of the Bardet-Biedel syndrome (the most frequent genetic cause
of obesity in humans).
To learn more about us, read our review "Functions of cell surface
heparan sulfate proteoglycans" in the 1999 Annual Review of
Biochemistry, or visit the Harvard Medical School Cell Biology web page:
http://cbweb.med.harvard.edu/research/bernfield. To apply, call or send
a CV and list of references to:
Merton Bernfield, M.D.
Enders 961
300 Longwood Ave.
Boston, MA 02115
Email: bernfield at hub.tch.harvard.edu
Tel: 617-355-6366
Fax: 617-355-7677
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