unprotection of groups

Juan L. Navia jlnavia at IX.NETCOM.COM
Tue May 27 20:34:01 EST 1997

kzhao at biovx1.biology.ucla.edu wrote:
> For Sunny's question of unprotection of glucuronide:
> Dissolve your compound in methanol (cold), flux ammonia for 1hr during stirring,
>  and store in a refrigerator o/n.  Acetate is recovered by filtration.  See
> J. Histochem. Cytochem. 2: 209-229, 1954 for details on similar compound.
> Good luck,
> Ke-Wei Zhao, Ph.D.
> Dept. Biol. Chem.
> UCLA School of Medicine
> Los Angeles, CA 90095

Any chance of ending up with glucuronamide under the stated conditions?
Might KCN/MeOH do better?  Mind you, careful of HCN vapors on work-up!


More information about the Glycosci mailing list

Send comments to us at biosci-help [At] net.bio.net