Dear Scientists,
Are there any databases on the Internet with information about which kind
of sugar-chains that are linked to different glycoproteins?
If not, can anyone tell me which of the following proteins (listed below)
that contains O-linked sugars (specially if they contain
Gal-beta-1-3-GalNac-ser/threo)?
I´m interested because I am working with a fungal lectin that have a
similar structure and localisation as the galectins from animals (the
galectins binds Gal-beta-1-3-GalNac-ser/threo) but my lectin seem´s not to
interact with this disaccharide or similar sequences but I have
conflicting data and I´m not 100 % sure. My lectin binds to porcine
stomach mucin and fetuin that contains this disaccharide and to sulfated
glycoconjugates (e.g sulfatide).
* + alpha2-macroglobulin (kininogen) (human)
* +? immunoglobulin A1 (human)
* +? immunoglobulin A2 (human)
* - alpha1-antitrypsin (human)
* - alpha1-acid glycoprotein (orosmucoid) (bovine)
* + alpha2-HS glycoprotein (human)
* + chymotrypsinogen A (bovine)
* - alpha-casein (bovine)
(+ means that my lectin binds to the protein and - no binding).
Thank you,
Stefan Rosén
Stefan Rosén
Department of Microbial Ecology
University of Lund
Ecology Building
S-223 62 LUND, SWEDEN
Telephone + 46 - 46 222 37 58
FAX + 46 - 46 222 41 58
E-mail Stefan.Rosen at mbioekol.lu.se
