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Artefacts with PAS-staining?

Robertson Davenport rddvnprt at umich.edu
Fri Oct 20 09:20:16 EST 1995

The PAS stain is based on oxidation of a 1,2 dialcohol to form a 
dialdehyde followed by a double Schiff reaction of sulfate with the 
aldehyde. So if a protein contains, or can be oxidized to, aldehyde 
groups, it may be PAS positive. 

Robertson D. Davenport, MD
Assistant Professor                    Associate Medical Director
Department of Pathology                Blood Bank and Transfusion Service
University of Michigan Medical School  University of Michigan Hospitals
rddvnprt at umich.edu

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