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Glycosyltransferase Inhibitors

Craig Webster Craig at broombio.demon.co.uk
Mon Nov 27 11:54:16 EST 1995


In article: <496ti5$bk0 at dux.dundee.ac.uk>  (k.c.breen at dundee.ac.uk) writes:
> 
> I was wondering if there are any commercially available inhibitors of
> terminal  
> glycosyltransferases (specifically sialyltransferase and
> galactosyltransferase). 
> In particular, I am interested in agents which can be used to treat cells
> in 
> order to subtly alter their protein glycosylation patterns. I have tried 
> mannosidase inhibitors, but these act at an early stage in oligosaccharide 
> elongation and processing to prevent the transfer of a number of terminal
> sugar residues
>
Would Tunicamycin be of any use in this case ?
 
-- 
Craig Webster              |  Tel: 01245 442700
Grade B Clinical Biochemist|  Fax: 01245 514077
Broomfield Hospital        |  email (work) cwebster at broombio.demon.co.uk
Chelmsford, CM1 5ET        |        (home) cwebster at bimbo.demon.co.uk




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