MAA lectin

Steven Pirie-Shepherd srps at galactose.mc.duke.edu
Thu Jun 22 08:20:14 EST 1995

I have a suspicion that the protein I am working on at the moment has an 
odd O-linked mannose or fucose that may act as an anchor for polysalic 
acid. I realise that polysialic must polymerise in the alpha(2-8) 
linkage, but it cannot link to mannose or fucose via that linkage can it? 
I am going to try to purify peptides on MAA, a lectin specific for 
alpha(2-3) linked sialic acid as I imagine that any polysialic acid must 
be linked to the rest of the sugar by a less esoteric linkage. Does this 
make sense to people, and does it sound feasible?

The structure I envisage is

	SA a(2-8)-n..-sa a(2-3/6)-HexO-amino acid

where n is any number of SA in the a(2-8) linkage and sa a(2-3/6)-Hex is 
the anchoring residue, via a 2-3 or 2-6 linkage to the neutral hexose.

Is my structure grossly impossible?


Steven Pirie-Shepherd		       		
srps at galactose.mc.duke.edu	        
"Insert your own pithy phrase just about here!"

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