Dear All,
The following is a draft FAQ (frequently asked questions) on the subject=
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of 'how many eukaryotic glycosyltransferases are cloned?' I emphasise that=
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this is a draft and I would welcome any comments/corrections or whatever=20
from anyone. Since cloning of glycosyltransferases is a fast moving area, I=
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am sure I have missed some of the papers or database accessions. This FAQ=20
will when corrected be sent back to the GLYCOSCI newsgroup and may then be=
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archived elsewhere on the Internet. I intend to follow this FAQ with one on=
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glycosidase specificity in due course. Comments to me (not to the list,=20
unless it is a general comment as to the concept of having FAQs of this=20
nature) by 9th March 1995 at wilson at edv1.boku.ac.at
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Regards,
Iain
Institut f=FCr Chemie der Universit=E4t f=FCr Bodenkultur, Wien, Austria
---------Draft FAQ begins
Q: 'Which eukaryotic glycosyltransferases are cloned?'
References to papers (first author, year, etc.) and to genbank (gb) and=20
Swissprot (sw:) accession numbers are given where possible.
N-acetylgalactosaminyltransferases=09
----------------------------------
alpha1,3 (blood group B) =09
human cDNA Yamamoto et al (1990) Nature 345:229-233
gb:j05175 sw:bgat_human
beta1,4 (GM2 synthase) =09
human cDNA Nagata et al (1992) JBC 267:12082-12087
gb:m83651 sw:cag2_human
CT antigen
Smith (1994) JBC 269:15162-15171
polypeptide =09
bovine cDNA Hamo et al (1993) JBC 268:12609-12616
Hagen et al (1993) JBC 268:18960-18965
gb:l17437/07780
N-acetylglucosaminyltransferases=09
--------------------------------
beta1,2 (GnT I) =09
human cDNA Kumar et al (1990) PNAS 87:9948-9952
gb:m55621 sw:ggnt_human
human gene Hull et al (1991) BBRC 176:608-615
mouse gene Pownall et al (1992) Genomics 12:699-704 =
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sw:ggnt_mouse
rabbit cDNA Sarkar et al (1991) PNAS 88:234-238
gb:m57301 sw:ggnt_rabit
beta1,2 (GnT II)
Schachter
beta1,4 (GnT III) =09
human cDNA Ihara et al (1993) J. Biochem.113:692-698
gb:d13789
rat cDNA Nishikawa et al (1992) JBC 267:18199-18204
gb:d10852
beta1,4 (GlcNAc terminating substrate)
Lymnaea Bakker et al (1994) JBC 269:30326-30333
gb: x80228
beta1,6 (GnT V) =09
rat cDNA Shoreibah et al (1993) JBC 268:15381-15385
gb:l14284
Saito et al (1994) BBRC 198:318-327
gb:d17716
beta1,6 (I-antigen)
Bierhuizer et al (1993) Genes Dev. 7:468-478
gb:z19550 sw:bgib_human =20
beta1,6 (O-linked) =09
human cDNA Bierhuizer (1992) PNAS 89:9326-9330
gb:m97347 =20
N-acetylglucosaminyl-1-phosphate transferases
---------------------------------------------=09
hamster Zhu & Lehrman (1990) JBC 265:14250-14255
gb:j05590 sw:gpt_crilo
Scocca & Krag (1990) JBC 265:20621-20626
gb:m36899 sw:uagt_crigr
Leishmania Liu & Chang (1992) Mol. Cell. Biol. 12: 4112-4122
gb:m96635
murine Rajput et al (1992) Biochem. J. 285:985-992
gb:x65603
yeast Hartog & Bishop (1987) Nucl. Acids Res. 15:3627
sw:gpt_yeast
Fucosyltransferases=09
-------------------
alpha1,2 =09
human cDNA Larsen et al (1990) PNAS 89:9326-9330
gb:m35531 sw:g2lf_human
alpha1,3/4 (FucT III) =09
human cDNA Kukowska-Latallo (1990) Genes Dev. 4:1288-1303
gb:x53578 sw:gft_human
alpha1,3 (FucT IV) =09
human cDNA Goelz et al (1990) Cell 63:1349-1356
gb:m65030/58596 sw:elft_human
human gene Kumar et al (1991) JBC 266:21777-21783
Lowe et al (1991) JBC 266:17467-17477
orangutan Koszdin (1992) BBRC 187:152-157
alpha1,3 (FucT V) =09
human gene Weston et al (1992) JBC 267:4152-4160
gb:m81485
alpha1,3 (FucT VI) =09
human gene Weston et al (1992) JBC 267:24575-24584
gb:l01698
Galactosyltransferases=09
----------------------
alpha1,3 =09
bovine cDNA Joziasse et al (1989) JBC 264:14290-14297
gb:j04989 sw:gatr_bovin
=09
murine cDNA Larsen et al (1989) PNAS 86:8227-8231
gb:m26925 sw:gatr_mouse
=09
murine gene Joziasse et al (1992) JBC 267:5534-5541
human psedogene Joziasse et al (1991) JBC 266:6991-6996
Larsen et al (1990) JBC 265:7055-7061
alpha1,3 (blood group A) =09
human cDNA Yamamoto et al (1990) JBC 265:1146-1151
sw:bgat_human
beta1,4 =09
bovine cDNA D'Agostaro et al (1989) EJB 183:211-217
gb:x14558 sw:nals_bovin
chicken (partial)Hathaway et al (1991) Glycobiology 1:211-221
gb:x14085/l12565
human cDNA Masri et al (1988) BBRC 157:657-663
Watzele & Berger (1990) Nucl. Acids Res. 18:7174
gb:m22921/70427 sw:nals_human
human gene Mengle-Gaw et al (1991) BBRC 176:1269-1276
murine cDNA Nakazawa et al (1988) J. Biochem. 104:165-168=20
Shaper et al (1988) JBC 263:10420-10428
gb:j03880 sw:nals_mouse
murine gene Hollis et al (1989) BBRC 162:1069-1075
gb:m27917-27923
rat (partial) Bendiak et al (1993) EJB 216:405-417
sw:nals_rat
LPG1 gene (possible galactofuranosyltransferase)
Leishmania Ryan et al (1993) PNAS 90:8609-8613
gb:l11348
Glucosyltransferases
--------------------
alg8
yeast gene Stagljov et al (1994) PNAS 91:5977
gb:x75929
alg5 (Dol-P-Glc synthetase)
yeast gene te Heesen et al (1994) EJB 224:71-79
gb:x77573 =20
Mannosyltransferases=09
--------------------
alpha1,2 =09
yeast gene Haeusler & Robbins (1992) Glycobiology 2:77-84
gb:m81110 sw:mnt1_yeast
alpha1,3 (Alg2)=09
yeast gene Jackson et al (1992) Glycobiology 3:357-364
beta1,4 (Alg1) =09
yeast gene Albright et al (1989) JBC 263:7042
gb:j05416 sw:alg1_yeast
Och1 =09
yeast gene Nakayama et al (1992) EMBO J. 11:2511-2519=20
gb:s40019 sw:och1_yeast
Dpm1 (Dol-P-Man synthetase)
yeast gene Orlean et al (1988) JBC 263:17499-17507
gb: j04184 sw:dpm1_yeast
Pmt1 (O-linked mannosylation)
yeast gene Strahl-Bahlsinger et al=20
gb:l19169 sw:dpmt_yeast
Oligosaccharyltransferase subunits=09
----------------------------------
Ribophorin I =09
human cDNA Crimaudo et al (1987) EMBO J. 6:75-82
sw:rib1_human
Swp1 =09
yeast te Hessen et al (1993) EMBO J. 12:279-284
Wbp1 =09
yeast te Heesen et al (1991) Eur J Cell Biol 56:8-18 =09
48K subunit
canine Silverstein et al (1992) JBC 267:23658-23663
Sialyltransferases=09
------------------
alpha2,3 (N-linked) =09
rat cDNA Wen et al (1992) JBC 267:21011-21019
gb:m97754
human Kitagawa (1993) BBRC 194:375-382
alpha2,3 (O-linked)=09
porcine cDNA Gillespie et al (1992) JBC 267:21004-21010
gb:m97753
mouse cDNA Lee et al (1993) EJB 216:377-385
gb:x73523
alpha2,3 (ST-4, sialyl LeX)
Sasaki et al (1993) JBC 268:22782-22787
gb:x74570
alpha2,3 (STZ, glycolipid)
Kitagawa (1994) JBC 269:1394-1401
gb:l23767
alpha2,3 (ST3GalA.2, glycolipid)
Lee et al (1994) JBC 269:10028-10033
gb:x76998/76999
alpha2,6 =09
human Bast et al (1992) J. Cell Biol. 116:423-435
Grundmann et al (1990) NAR 18:6670
gb:x62822 sw:cags_human
rat cDNA Weinstein et al (1987) JBC 262:17735-17743
gb:m54999 sw:cags_rat
rat gene Svensson et al (1990) JBC 265:20863-20868
alpha2,6 (O-linked, EC 2.4.99.3)
Kurosawa et al (1994) JBC 269:1402-1409
gb:x74946
alpha2,8
rat JBC 268:11504-11507
STX1
Livingston (1993) JBC 268:11504-11507
gb:l13445
------------end of FAQ
