Iain Wilson <wilson at edv1.boku.ac.at> wrote in
Message-Id: <3moa8g$h29 at mail.boku.ac.at>
>>treefrog at u.washington.edu (Bryce Chackerian) wrote:
>>>> A recent report indicated that the drugs A23187 and thapsigargin inhibit
>> O-linked glycosylation. Does anyone out there know who makes these drugs
>> and if you can purchase them. Apparently a company called L.C. Labs in
>> Woburn, Mass manufactures thapsigargin; has anyone heard of them and/or
>> send me their phone number?
>>>> Thanks in advance
>> Bryce Chackerian
>> Dept. of Microbiology
>> U of Washington
>>A quick look at the 1995 Sigma catalogue shows that thapsigargin
>(potent cell permeable IP3-independent intracellular calcium
>releaser and inhibitor of microsomal Ca-ATPase) is listed. Price
>127.10 Deutschmarks for 500 micrograms. Also, under calcium
>ionophore A23187 is listed a number of forms of either free acid
>or salts - starting from around 32 DM per mg. (For some reason
>even though Sigma have a 'Austrian' catalogue, the prices are in DM!)
>As for L.C. Labs, never heard of them!
>>Iain
>>---------------------------------------------------------------
>Iain Wilson Institut f|r Chemie
>Tel: 43-1-47654-6065 Universitdt f|r Bodenkultur
>Fax: 43-1-310-5176 Gregor-Mendel-Stra_e 33
>E-mail: wilson at edv1.boku.ac.at A-1180, WIEN, Austria
>>http://www-bprc.mps.ohio-state.edu/cgi-bin/hpp/iain_wilson.html>>
Hi all,
from the Massachussets phonebook:
LC Laboratories
1651 (or 165T) New Boston
Woburn, MA 01801
617-938-1700
In addition to the above and Sigma, A23187 and Thapsigarin are also
available from:
BioMol
5166 Campus Drive
Plymouth Meeting, PA 19462 USA
Phone: 800-942-0430 or 610-941-0430
FAX: 610-941-9252
By the way, I would be interested in the reference that describes
the o-glycosylation inhibiting activity of Thapsigarin.
Thanks,
Brad
Disclaimer: No commercial interest in the above companies other
than as a satisfied customer.
-------------------------------------------------------------
Bradley Turner
University Hospital
Boston University PHONE: 617-638-8346
Medical Center FAX: 617-638-7785
Gastroenterology, E-201 EMAIL: bturner at med-itvax1.bu.edu
88 East Newton Street bsturner at water.bu.edu
Boston, MA 02118, USA bsturner at mbcrr.harvard.edu
-------------------------------------------------------------
