treefrog at u.washington.edu (Bryce Chackerian) wrote:
>> A recent report indicated that the drugs A23187 and thapsigargin inhibit
> O-linked glycosylation. Does anyone out there know who makes these drugs
> and if you can purchase them. Apparently a company called L.C. Labs in
> Woburn, Mass manufactures thapsigargin; has anyone heard of them and/or
> send me their phone number?
>> Thanks in advance
> Bryce Chackerian
> Dept. of Microbiology
> U of Washington
A quick look at the 1995 Sigma catalogue shows that thapsigargin
(potent cell permeable IP3-independent intracellular calcium
releaser and inhibitor of microsomal Ca-ATPase) is listed. Price
127.10 Deutschmarks for 500 micrograms. Also, under calcium
ionophore A23187 is listed a number of forms of either free acid
or salts - starting from around 32 DM per mg. (For some reason
even though Sigma have a 'Austrian' catalogue, the prices are in DM!)
As for L.C. Labs, never heard of them!
Iain
---------------------------------------------------------------
Iain Wilson Institut für Chemie
Tel: 43-1-47654-6065 Universität für Bodenkultur
Fax: 43-1-310-5176 Gregor-Mendel-Straße 33
E-mail: wilson at edv1.boku.ac.at A-1180, WIEN, Austria
http://www-bprc.mps.ohio-state.edu/cgi-bin/hpp/iain_wilson.html
