Barry Hardy bhardy at convex.ox.ac.uk
Tue Dec 13 13:18:37 EST 1994

                                2ND ANNOUNCEMENT
		              April 23-26, 1995
                                Elsinore, Denmark

        European Commission DGXII, European Congress of Biotechnology 5,
                       Novo Nordisk A/S, Denmark.
            Nordic Fund for Technology and Industrial Development

It is a pleasure for us to invite you to participate in the Carbohydrate Bioengineering Meeting scheduled for April 23-26, 1995, at the LO-School in Elsinore, Denmark. The meeting is also planned to be the first annual meeting for the EC Biotech Carbohydrate Active Enzyme Projects.

Over the last decade we have witnessed a virtual explosion in our knowledge about both the function and structure of carbohydrates as well as the proteins they are interacting with. We are convinced that it is both a timely and relevant activity to provide an international forum, where
we can discuss the latest research results with a particular emphasis on industrial and medical implications. It is becoming increasingly clear that carbohydrates and derivatives thereof have important roles in all biological systems. Many processes involving molecular recognition are either facilitated or modulated by carbohydrates. Concurrent with the revolution in microbiological techniques, we have available a host of new promising or significantly improved existing techniques for obtaining 3D structural information with high relevance for developing
a detailed molecular understanding of the often complex interaction between carbohydrates and the enzymes or proteins they interact with.

The Carbohydrate Bioengineering Meeting will aim at providing a forum where some of the foremost researchers in the area will present their latest results obtained and selected participants will be invited to give oral as well as poster presentations. We aim at providing a stimulating and open scientific atmosphere for both the established professionals in industry and academia as well as for students. Pending sponsorship we will try to offer reduced rates for a limited number of students.

The Organizing Committee

Sven Pedersen, Novo Nordisk, Denmark
Birte Svensson, Carlsberg Laboratory, Denmark
Steffen B. Petersen, SINTEF UNIMED,
MR-Center, Norway   
Scientific Advisory Board

R. Dwek, UK - B. Henrissat, F 
K. Bock, DK - J. Dordick, US  
R. Haser, F - O. Smidsrd, N
T. Feizi, UK

Conference Secretariat:
    Mona K. Eidem
    N-7034 Trondheim, Norway
    Phone +47 73 99 77 00
    Fax +47 73 99 77 08
    (email: sbp at marvin.mr.sintef.no)


Ali, Simi - UK
Targeted expression of microbial cellulases in transgenic animals

Andresen, Otto - DK 
Ethyl glucoside esters of fatty acids, a unique class of surfactants

Colman, Peter M. - AUS
Design and properties of carbohydrate-based inhibitor of influenza virus

Davies, Gideon - UK 
Structures of fungal cellulases

Dijkhuizen, Lubbert - NL
Protein engineering of CGTase from Bacillus circulans strain 251

Dordick, Jonathan S. - USA
Chemoenzymatic modification of sugars and sugar derivatives for synthetic and
polymeric applications.

Driguez, Hugues - F
Thiooligosaccharides: Toys or Tools for the studies of glycanases

Feizi, Ten - UK  
New approaches to harnessing carbohydrate-mediated cell effector function

Hart, Gerald W. - USA  
Temporal glycosylation of nuclear and cytoskeletal proteins

Johnson, Louise N. - UK 
Enzyme-carbohydrate recognition for catalysis and drug design

Kofod, Lene V. - DK 
Application of  cloned monocomponent carbohydrases for modification of plant

Kulbe, Klaus - A
On the continuous transformation of various mono- and disaccharides by
 unspecific oxidoreductases

Nilsson, Bo - S   
Analysis of protein glycosylation by mass spectroscopy

Paulson, James C. - USA 
Carbohydrate blockers of leukocyte mediated disease

Petersen, Steffen B. - N  
Electrostatic studies of carbohydrate active enzymes

Remaud-Simeon, M. - F 
Studies of recombinant amylosucrase

Robyt, John F. - USA  
Mechanism and action of glucansucrases

Rossi, Mos
Properties, production, structure and applicative prospects of the  -glycosidase
isolated from extremophile Sulfolobus solfataricus

Schinzel, Reinhard - D 
Carbohydrate binding at the active site of E. coli maltodextrin phosphorylase

Schrempf, Hildgund - D
The chitinolytic system of Streptomyces olivaceoviridis

Sharon, Nathan - ISR
Glycans of glycoconjugates as modulatory and recognition molecules

Soetaert, Wim - D  
A wide range of carbohydrate modifications by a single microorganism:
Leuconostoc mesenteroides

Spener, Friedrich - D  
Development of a novel enzyme based glucose sensor

Svensson, Birte - DK   
Mutational analysis of catalytic mechanism and specificity in amylolytic

de Taxis, du Poet, Ph. - B
The EC Biotech and the 4th Framework Programme

Teeri, Tuula - SF
Modes of action of two cellobiohydrolases from Trichoderma reesei.

van Halbeek, Herman - USA 
NMR studies of structure and dynamics of carbohydrates in solution.

Warren, Tony - CAN
Interactions of cellulases from Cellulomonas fimi with cellulose

Welinder, Karen G. - DK
Effects of glycosylation on protein folding, stability and solubility. Studies of
engineered and chemically modified fungal and plant peroxidases

Willmitzer, Lothar - D 
Transgenic plants as a tool to understand starch biosynthesis

Withers, Stephen G. - CAN   
Enzymatic cleavage of glycosides: How does it happen ?




Before January 20, 1995 - reduced registration and accomodation rate. Registration after January 20 is of course also possible, but at an increased rate, because the hotel reservations have to be confirmed on this date.

Registration fee:

Before Jan 20 : 4700 DKK - After Jan 20th 5500 DKK
The registration includes: Participation, proceedings to be published by 
Elsevier after december 95, accomodation (arr Apr. 23, dep apr. 26) including
all meals. If you are not interested in accomodation the registration fee is
2800 DKK - including proceedings and all meals.

Poster abstract deadline: 

March 1, 1995. Please submit a laserprint hardcopy of your poster abstract (approx. 1-2 A4 pages) in addition to a DOS diskette with the document written in WordPerfect or MS Word.



Structure of Carbohydrates

Biological function and interaction is intimately linked to the 3D
structure and dynamics of the molecules involved. The carbohydrates
represent a special challenge because of their intrinsic flexibility and
complex structural features. This session will aim at providing an
overview of the current knowledge about the structure and dynamics
of carbohydrates.

Structure and function of Carbohydrate active enzymes

This session will focus on the structure function relationship of
carbohydrate active enzymes. With the ever-increasing number of 3D
structures that have been determined by X-ray diffraction analysis,
our understanding of the often intricate features of carbohydrate
active enzymes is also growing. A special emphasis will be given to
the structural interpretation of binding and catalysis of carbohydrates.

Applications of protein engineering

The protein engineering of carbohydrate metabolizing enzymes and
their application in glycotechnology will be discussed in this session.
The topics include analysis of structure/function relationships,
crystallographic analysis and modelling of enzyme-ligand complexes,
design and application of enzymes with altered specificity.

Carbohydrates in Medicine

Enzymatic modification/synthesis of therapeutic carbohydrates and
the mechanism of action of their biological activity are to be
discussed in this session. The session, as well as posters, intend to
cover both protein-bound saccharides as well as oligo-/poly-
saccharides and topics such as vaccine antigens, antivirals,
antibacterials and cell adhesion blockers.

Oligo- and Polysaccharides of industrial interest 

Production of novel oligosaccharides, that can be used for animal
feed to improve the animal's weight gain and health and for human
nutrition to provide calorie-reduced diets and to promote bifido-
bacteria growth are examples of topics for this session as well as
enzymatic modification of plant polysaccharides (gums).

Production of Carbohydrate containging new materials

Enzymatic synthesis of novel materials is the target for this session.
Examples are sugar-containing polymers, which are receiving
increasing attention as they may permit biocompatibility and
biodegradibility and surfactants such as alkylglucosides.

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