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Generalized LOD score??

Mike Morris mike at divsun.unige.ch
Thu Sep 29 02:30:20 EST 1994


Hmmmm,
  I have the following simple linkage problem:
  We are a studying a disease which is perfectly linked to two markers,
which are approximately 1 cM apart. We have a small consanguineous family,
which gives us a lod (theta=0) of 3.09 for one marker and 2.2 for the
other.
  The problem: when I run ilink and then lrp, I get a "generalized lod
score" of 5.06, for the three possible locus orders. 
  What is a generalized lod score? How is it calculated? Why is it higher 
than my better marker?
thanks in advance,  
  Mike
*******************************************************************
Michael Morris PhD            
Division of Medical Genetics       tel (Switzerland) (22) 702.56.94
CMU, University of Geneva          fax (Switzerland) (22) 702.57.06
Geneva, Switzerland                email mike at medsun.unige.ch                  




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