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Two-point analyses

Pierre Janssens pj at anat.uct.ac.za
Fri May 20 03:36:15 EST 1994


When doing two point analyses: affection status vs. locus, I would like to 
know what is the better indication that a given locus is closer to the 
disease locus.

I have the following scenario:
Marker A is linked to the disease locus with a maximum 
lodscore at a certain recombination fraction, but marker B presents 
with a higher lodscore (than the maximum I got for marker B), however its 
lodscore maximum occurs at higher recombination fraction.

Any easy way to test which of the two markers would be closer to my disease 
locus, short of doing multipoint analyses?

Thanks to all who pointed me in the right direction to enable me to use Mlink 
with more than 5 alleles. Recompiling was a piece of cake!

Thanks very much,

Pierre Janssens
Department of Human Genetics
UCT Medical School
Cape Town
South Africa

pj at anat.uct.ac.za



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