I have genotyped two RFLP type markers on an incomplete set of CEPH
pedigrees. I want to do linkage to find more informative markers close
to my markers. I know the chromosomal localization of my genes of interest.
I expect that I should be able to download genotype data from the CHLC
server, and then integrate my marker that way. Unfortunately, I have no
experience with this, and don't know anyone around Stanford that does.
I would really appreciate it if someone would send me, or post information
to get me started. For example, how do I find out more about "Crimap" and
what the required data format is? Is Crimap data interpreted by the "linkage"
suite of programs, or is there a crimap program? I am planning to try to put
my limited CEPH data into this crimap format to be in the same format as
CHLC data, and then pull CHLC genotype data from my set of CEPH pedigrees in
the regions that I know my gene lies, and then use that as the data set for
doing the linkage analysis. Does this sound like the best approach?
faraco at cmgm.stanford.edu