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Allele frequencies

wijsman at max.u.washington.edu wijsman at max.u.washington.edu
Mon May 16 22:24:29 EST 1994

> What is the influence of having allele frequencies not add up to 1, eg. when 
> some alleles are not present in a pedigree under study. What is the best 
> approach to this kind of problem?

Best approach is to specify n+1 alleles, where there are n alleles
actually observed in the pedigree.  Use the correct allele frequencies
for the n alleles, and for the n+1th allele, use 1 minus the sum of
the frequencies of the observed alleles.

Ellen Wijsman
Div of Medical Genetics, RG-25
and Dept of Biostatistics
University of Washington
Seattle, WA   98195
wijsman at u.washington.edu

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