To all the experts:
Suppose you would do research on a very complex disease like asthma
and hypertension. You know only some population frequencies and you
expect a genetic component in some families - but you don't know any
mode of inheritance. No strong candidate genes exist. How would you
start a study? Collect families for the haplotype relative risk method?
Look for affected sib pairs? Or do a linkage analysis in large pedigrees?
Something else? All opinions are welcome.
WJST at GSF.DE