Fixed-term: The funds for this post are available for 8 months in the first instance.
Applications are invited for a post-doctoral research associate to join the group of Dr Bernardes at the Department of Chemistry, University of Cambridge to work on the ERC Starting Grant “TagIt”. The role is to design and apply new methods that allow the re-design of the structure and function of proteins without sequence engineering, i.e., targeting naturally ocurring amino acids. The method will be used to conjugate drugs to proteins that target specific biomarkers in the context cancer.
The successful candidate will perform reaction engineering in aqeous solution to apply in the context of site-selective protein modification. This will consist of reaction optimisation and synthesis of suitable reagents, test the conditions developed at the protein level, purify and characterise (mass spectrometry and biophysical measurements such as SPR and CD), and generation of a protein-drug conjugate.
The successful candidate will have (or be about to obtain) a PhD in chemical biology/synthetic chemistry. They will be highly motivated and able to work independently. Excellent organisational and interpersonal skills are required to ensure success in liaising with a large and diverse research team. Previous experience with bioconjugation chemistry and purification and charaterisation of protein conjugates by advanced mass spectrometry is desirable.
For instructions on how to apply, please refer to: http://bit.ly/2GzTrkS