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[Computational-biology] postdoc: theory/bioinformatics of evolutionary capacitors

Joanna Monti-masel masel at U.Arizona.EDU
Thu Jun 8 17:37:11 EST 2006

Postdoc position: theoretical population genetics and bioinformatics of

Evolutionary capacitor mechanisms such as alternative splicing and the
heat shock protein Hsp90 store variation in a latent form and reveal it
later. Capacitors appear to be common, and could have a significant impact
in facilitating evolution. The project is to develop theoretical
population genetic models of evolutionary capacitance in finite
populations, and to test predictions of the models in the case of the
yeast prion [PSI+] using a bioinformatic / comparative genomic approach. A
variety of concepts in evolutionary biology will be explored and made
rigorous, including evolvability, preadaptation and genetic assimilation.

The postdoc will work with PI Joanna Masel
(http://eebweb.arizona.edu/Faculty/bios/masel.html) at the University of
Arizona in Tucson. NIH funding is secured, and the position is renewable
over multiple years. Preferred start date is Aug 1 2006. Ph.D. with strong
quantitative background and computational and/or modeling experience is
required. Prefer experience in some of: bioinformatics, comparative
genomics, evolutionary theory, computational methods based on linear
algebra, other algorithm experience, finite Markov chains, PERL, MySQL,
other computational or mathematical biology. Apply at
or contact Joanna Masel at masel at u.arizona.edu for more information.

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