WELLCOME SUMMER SCHOOLS
FOURTEENTH ADVANCED COURSE 16th - 21st July 1995
The Wellcome Trust Centre for Human Genetics, University of Oxford
Windmill Road, Headington, Oxford, OX3 7BN
All email inquiries to: wss at umds.ac.uk.
HUMAN GENOME ANALYSIS: GENETIC ANALYSIS OF MULTIFACTORIAL DISEASES
An intensive computer-based course aimed at scientists actively involved
in genetic analysis of multifactorial traits. The following topics will be
1. Gel analysis
Operation of GENESCAN software for defining tracks and checking size
standards on the ABI fluorescent 373A DNA sequencer. Including sample sheet
set up, installation of matrix files, analysis and pre-process parameters.
Scoring of microsatellite results using GENOTYPER and GAS software,
including setting up of macros files, export of data, allele binning and
Introduction to basic concepts of linkage analysis, in particular, those
related to non-Mendelian diseases.
4. Sibpair Analysis
Comparison of identity-by-descent, identity-by-state and maximum
likelihood methods of affected sib-pair analysis. Analysis of quantitative
5. Lodscore analysis
Use of LINKAGE program to calculate likelihoods for general pedigrees,
including construction of locus linkage maps, error checking and analysis of
marker locus linked to disease.
6. Affected Relative Methods
General non-parametric tests aimed at detecting linkage by examining
correlation between the affected members of a pedigree.
7. Associated Tests
Use of tests for linkage disequilibrium between markers and disease,
construction and analysis of haplotypes.
Teaching will take the form of lectures by invited speakers, informal
tutorials, hands-on computer sessions and analysis of disease family data
sets. There will also be an opportunity to analyse and discuss
participants' own data sets.
SUMIT BHATTICHARYYA, HEATHER CORDELL, JUNE DAVIES, SIW DANIELS, TONY
MERRIMAN, LYNN PRITCHARD, PETER REED, JOHN TODD, JOE TERWILLIGER, MARGARET
TOWN, DAN WEEKS, ALAN YOUNG.
Confirmed speakers include:
MIKE BOEHNKE (Ann Arbor), ARAVINDA CHAKRAVARTI (Case Western), DOUG EASTON
(Sutton), MARTIN FARRALL (Oxford), MARK LATHROP (Oxford), MARGARET
Applicants should be scientists at an advanced level of research
(post-doctoral or equivalent). Documentation verifying that the applicant
is actively engaged in a linkage or family-based association study
(animal/human) must be provided with the application, as well as evidence of
access to a fluorescence-based automated genotyping system. The course is
subsidised by the Wellcome Trust for scientists based in academic
institutions anywhere in the world. This is a residential course, without
exception, and there is a charge of 350 pounds Sterling towards board and
There are no formal application forms, but applicants should send a hard
copy of their full CV together with a 300 word outline of their research
plans and supporting documentation, to Dr Pelin Faik, Course Co-ordinator,
Division of Biochemistry & Molecular Biology, UMDS, Guy's Campus, London
Bridge SE1 9RT.
Tel: 0171 403 6998
Fax: 0171 407 5281
Email: wss at umds.ac.uk.
Closing date for applications is 14th April 1995
/ \ / | / Alan Young @ uk.ac.ox.vax
/____/ / ___ __ |___/
/ / / / | / | / "The bigger they are,
/ \_/\__\__/|_/ /_________/ the harder they fall on you."