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Wed Dec 21 11:19:44 EST 1994

                     *      COURSE ANNOUNCEMENT      *



This intensive four day course centers on mapping human genetic diseases.
The concentration is on the entire disease mapping process, including
clinical classification, pedigree collection, molecular genetic analysis,
statistical analysis, and gene characterization.  The course emphasizes the
global decision-making process, rather than details of specific techniques.
A residential conference center setting promotes extensive interaction
between the students and the internationally recognized faculty.

Course goals:

1.   To outline and instruct participants about the necessary steps and
     procedures used in ascertaining and collecting pedigree data and
     clinical and family history information.

2.   To discuss in detail both the molecular and statistical methodologies
     for using the reference marker maps generated by the efforts of the
     Human Genome Initiative.  Emphasis will be on working examples and the
     basic theory behind genetic mapping methodologies.

3.   To educate participants on the general interpretation of linkage
     results for both simple and complex disorders.  Discussions will
     include an overview of positional cloning strategies, refinement of
     the preliminary linkage data, investigation of power, examination of
     heterogeneity, physical mapping, cDNA analysis, exon amplification,
     etc.  This course will not include any bench or "wet" laboratory


Margaret A. Pericak-Vance, Ph.D., Department of Medicine, Department of
Genetics, Duke University School of Medicine.  She is a founding fellow of
the American College of Medical Genetics (ABMS) and a board-certified Ph.D.
medical geneticist with fourteen years experience in genetic counseling.
Dr. Pericak-Vance is a genetic epidemiologist whose research has focused on
mapping the human genome with emphasis on the mapping of genetic disorders,
with more recent extensions into complex genetic disease.  She has
concentrated on neurogenetic diseases, actively mapping such disorders as
familial amyotrophic lateral sclerosis (Lou Gehrig disease), tuberous
sclerosis, and late onset Alzheimer disease (AD).  She is a member of the
Mammalian Genetics Study Section at NIH.

Jonathan L. Haines, Ph.D., Department of Neurology, Massachusetts General
Hospital, Harvard Medical School.  Dr. Haines is a genetic epidemiologist
whose research has focused on both human disease and general (reference)
chromosome mapping.  Dr. Haines has concentrated on neurogenetic diseases,
including the mapping of familial amyotrophic lateral sclerosis, familial
Alzheimer disease, Huntington disease, tuberous sclerosis, neurofi-
bromatosis, and multiple sclerosis.  Dr. Haines is presently an editor of
chromosome 9 for the Genome Data Base (GDB).  He is an associate editor of
Genomics and an editor of Current Protocols in Human Genetics.


Arthur S. Aylsworth, M.D., Division of Genetics and Metabolism, Department
of Pediatrics, The University of North Carolina at Chapel Hill.  Dr.
Aylsworth is a board-certified pediatrician and clinical geneticist.  As a
physician-scientist, Dr. Aylsworth plays primary roles in family
ascertainment and phenotypic delineation.  He is actively involved in
studies on neurofibromatosis and neural tube defects.

David Goldgar, Ph.D., Genetic Epidemiology, Department of Medical
Informatics, University of Utah.  Dr. Goldgar is a statistical geneticist
with extensive experience in both the theoretical and practical aspects of
mapping human quantitative and complex traits.  He has concentrated on the
genetic epidemiology of common cancers, focusing on the genetic mapping of
breast and ovarian cancer.  He is actively involved in several large
pedigree ascertainment and collection studies.

Deborah A. Meyers, Ph.D., Department of Medicine, The Johns Hopkins
University.  Dr. Meyers is a statistical geneticist who has concentrated
her research on the genetic basis of complex disorders including allergy
and psychiatric diseases such as schizophrenia and Alzheimer disease.  She
has extensive didactic experience in her teaching role at the short course
in Medical and Experimental and Mammalian Genetics, The Jackson Laboratory,
Bar Harbor, Maine.

Jeffrey Murray, M.D., Department of Pediatrics, University of Iowa.  Dr.
Murray is a molecular biologist and physician scientist with extensive
experience in both general chromosome and disease gene mapping.  Dr. Murray
is a board-certified pediatrician and clinical geneticist.  His research
interests include genetic studies in cleft-lip and palate.  He also directs
a national effort to generate a high resolution genetic map of the entire
genome.  Dr. Murray is a GDB Editor for chromosome 4 and a former member of
the Mammalian Genetics Study Section at NIH.

Marcy C. Speer, M.S., Ph.D., Department of Medicine, Duke University
Medical School.  Dr. Speer is a board-certified genetic counselor with
eleven years of experience.  She is also a genetic epidemiologist whose
research interest is in mapping human genetic diseases, including the
muscular dystrophies and neural tube defects.  She is also involved in
studies of unusual genetic phenomena such as anticipation and imprinting.


Participation in the course will be dependent on completion of an
application form that describes the applicant's background and research
interests and will be limited to 36 students.  All participants will need
to show evidence of a postgraduate genetics course or its equivalent.
Participants must provide a brief statement describing their research
interests, their reason for taking the course, and their long-term
objectives in relation to the course curriculum.  This information will be
used to select a highly motivated participant group.  Minority and women
applicants are specifically encouraged to apply.  A limited number of
scholarships are available for registered students or fellows.  Scholarship
selection will be based on the strength of the individual applications.


The course will be held at the R. David Thomas Center located on the campus
of Duke University, Durham, NC.  The Thomas Center is a new facility which
establishes a climate of hospitality and an atmosphere conductive to
learning and to the exchange of ideas.  Both students and faculty will be
housed at the R. David Thomas Center.


                   March 25-29, 1995

Deadline for completed application:

                   January 2, 1995

For information and application forms contact:

Write:   Genetic Methods Course
         c/o Dr Margaret Pericak-Vance
         Division of Neurology, Box 2900
         Duke University Medical Center
         Durham, NC  27710


E-Mail:  genclass at genemap.mc.duke.edu

In any correspondence, please include a postal address

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