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Garfinkel et al. (was Re: Is it Metabolic Control THEORY orMetabolic Control ANALYSIS)

Herbert M Sauro hsauro at cds.calxxxtech.edu
Tue Aug 22 16:12:25 EST 2000


What perfect timing, I was looking for material which might explain to me
the ins and outs of modelling enzymes bound to membranes. I shall check out
the refs you mentioned.

Herbert Sauro

"claude aflalo" <aflaloc at bgumail.bgu.ac.il> wrote in message
news:Pine.OSF.4.21.0008220935070.27600-100000 at sansana.bgu.ac.il...
>
>
> Petr, the alternative, more rigorous approach to membrane-bound enzyme
> kinetics originate basically from the Chemical Engineering field; it
> differentiates between intrinsic (microscopic, as in solution) and
> inherent (solely resulting from their physical state) properties of
> immobilized enzymes. The combination of both yields the effective
> properties of the catalytic system (macroscopic, as observed out of the
> black box).
>
> The latter, most often dealt-with by most biologists, yield a distorted
> picture of the system's behavior, especially when the interpretation of
> the results is based on a (tacite) assumption that "ideal" conditions
> prevail...
>
> If you're interested please refer to this central (relatively recent)
> review:
> *Engasser, J.-M. and C. Horvath (1976). Appl. Biochem. Bioeng. 1:127-220.
>
> A fascinating discussion, pertaining to the effective consequences of
> enzyme organization can also be found at:
> *Ricard, J., N. Kellershohn, et al. (1989). Spatial order as a source of
> kinetic cooperativity in organized bound enzyme systems. Biophys J
> 56:477-487.
>
>
> Claude Aflalo ########################## Phones: Office 972-7-6472118 ####
> Unit for Science Teaching/Dept. of Life Sciences    Lab 972-7-6472119
> Ben Gurion University of the Negev                  Fax 972-7-6472890








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