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Purine Biosynthesis

Jeremy Murray bmbjmm at bmb.leeds.ac.uk
Sat Mar 27 17:38:49 EST 1999


Ronald Koder wrote:

> I recently saw a seminar in which someone spoke about the purine pathway
>
> enzymes
> within the mitochondria.  They were proposing that the enzymes formed
> big complexes
> with one other and that substrates channel from one enzyme to the next
> in the pathway
> without being released into solution.  A good deal of their evidence was
>
> of the negative
> variety: i.e. the rates of purine formation could not be described using
>
> combinations of the
> rates constants determined for the individual enzymes.
>
> This was a pretty cool idea, and evidently not a new one.  As it seems
> to fall squarely
> within the boundaries of this news group,  I decided to hear what other
> people on
> this list thought about it.
>
> Ronald Koder
> The Institute for Biophysical Research on Macromolecular Assemblies
> The Johns Hopkins University

dude
check out Athel C-B
http://ir2lcb.cnrs-mrs.fr/~athel/homepage.htm
and metabolic control analysis

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Jeremy Murray                            MAIL: bmbjmm at bmb.leeds.ac.uk
Biochemistry & Molecular Biology         TEL:  +44 113 233 2591
Leeds University, LEEDS LS2 9JT          FAX:  +44 113 233 3167
        http://www.smb.leeds.ac.uk/wwwsb/jez.html
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