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post-doc position available

Guy C Brown gcb at mole.bio.cam.ac.uk
Fri Jun 12 03:58:37 EST 1998

Post-doc position available from 1 August 1998.

Jointly supervised by Dr Guy Brown at the Department
of Biochemistry, University of Cambridge, and 
Prof Salvador Moncada at University College London.
The project is on the regulation of mitochondrial respiration
and cellular function by nitric oxide (NO) from endothelial
cells.  NO can reversibly inhibit mitochondrial respiration
which may be involved in physiological regulation of energy
metabolism, whereas when NO reacts with superoxide to produce
peroxynitrite mitochondria are irreversibly damaged and this
may be involved in inflammatory, neurodegenerative, and 
ischaemic pathologies.  We have found that endothelial cells,
macrophages and astrocytes do indeed regulate cellular 
respiration via NO, and this may be involved in a variety
of physiological and pathological processes.  The project
will involve primary culture of endothelial cells and
vascular smooth muscle cells, nitric oxide and oxygen electrodes,
fluorescence and optical spectroscopy, biochemical assays,
and assays of apoptosis and cell death.  Experience of cell
culture, cell death, biochemistry, bioenergetics, and metabolism
are the main requirements for this job.  The position is funded by 
the Biotechnology and Biological Sciences Research Council of the 
UK for two and a half years at the standard salary rates, and will
be based in Cambridge.

Applications (with CV and two references) and informal enquiries 
to Dr Guy Brown, Department of Biochemistry, University of Cambridge, 
Tennis Court Road, Cambridge CB2 1QW, Tel: 01223 333342, 
Fax: 01223 333345, e-mail: GCB at MOLE.BIO.CAM.AC.UK

Dr Guy C. Brown
Department of Biochemistry,
University of Cambridge,
Tennis Court Road,
Cambridge CB2 1QW, UK.
Tel: (44) (0)1223 333342
Fax: (44) (0)1223 333345
e-mail: gcb at mole.bio.cam.ac.uk

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