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Flux distribution in TCA cycle

Miriam van Santen miriam at nibh.go.jp
Fri Jan 19 00:16:05 EST 1996


Hello,
I'm working on a computer simulation model of the TCA cycle. I'm trying 
to find out if there is anything known about the flux distribution from 
isocitrate to either succinate and glyoxylate or a-ketoglutarate. The 
concentration of malate, succinate and p-enol-pyruvate have a negative 
feedback on the conversion of isocitrate into succinate and glyoxylate. 
Is there a mathematical description for these inhibitions known?

Thanks in advance.

Miriam van Santen
emailnr: miriam at nibh.go.jp




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