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cAMP/G protein Rc binding

John Ireland jireland at saucer.cc.umr.edu
Mon Mar 14 23:12:14 EST 1994


I have read some articles that suggets that during the act of GTP binding
when the Gs alpha protein disaccosiates from the the G beta-gamma subunits
of the G protein complex that this lowers the affinity of a hormone
receptor for its hormone substrate.  If this is true, could anyone please
tell me a physical reason why or references that might know.  Thank you
for your time.

John Ireland
jireland at umr.edu
University of Missouri-Rolla
Chemistry Department



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