Does anyone out there know of any reviews or other references describing
enzymes or classes of enzymes which are responsible for reduction of
nitro- groups on nitroaromatics or other xenobiotic compounds? In vivo,
these nitro groups are often converted to amino-groups. This has been
well documented through radiolabeled metabolite studies. However, these
studies rarely examine the enzymes involved.
I have read up on nitrate and nitrite reductase enzymes, but so far
have found nothing to suggest that these enzymes act on anything other
than free nitrate/nitrite.
I would very much appreciate any references you can suggest.