[Bio-software] Identification of Druggable Sites for Protein-Protein Interaction Targets

Jim Prudhomme via bio-soft%40net.bio.net (by jprudhomme from healthtech.com)
Wed Mar 2 14:38:12 EST 2011

Cambridge Healthtech Institute & Bio-IT World Announce Upcoming Short

Identification of Druggable Sites for Protein-Protein Interaction Targets
June 8, 2011 (6:00 - 9:00 p.m.)

Royal Sonesta Hotel Boston, Cambridge, MA

Register at https://chidb.com/register/2011/sbd/reg.asp

On June 8, 2011, a dinner short course (6:00 - 9:00 p.m.) will take place at
the conclusion of day one of CHI's Eleventh Annual Structure-Based Drug
conference. Delegates attending CHI's Structure-Based Drug Design conference
are invited to attend, as well as others from the local area.


About the course:

Despite the growing number of examples of small molecule inhibitors that
disrupt protein-protein interactions (PPIs), the origin of druggability 
is poorly understood. This course is designed to demonstrate the use of
computational methods to determine the most likely structure of the 
complex formed by interacting proteins, identify potentially druggable sites
in the interface, determine whether the target is druggable, and
provide information on potential ligands. Participants will study a number
of targets using web-based software (including PIPER and ClusPro, 
currently the best protein docking tools available) on their laptops. A
light dinner will be served.


Course Instructors:

Sandor Vajda, Ph.D., Professor, Departments of Biomedical Engineering and
Chemistry, Boston University

Dima Kozakov, Ph.D., Research Assistant Professor, Departments of Biomedical
Engineering, Boston University


.         The problem of disrupting protein-protein interactions 

.         Predicting the structure of protein-protein complexes using
fragment-based identification of binding hot spots 

.         Druggability of binding sites determined by the hot spots 

.         Identification of functional groups with preferential binding to
hot spots 

.         Comparison of computational and experimental approaches. 


Additional information and registration details for this course and
conference is available at http://www.healthtech.com/sbd
or call CHI at 781-972-5400.

A separate registration is required to attend the Structure-Based Drug
Design conference that is scheduled for June 6-8, 2011. 

If you would like to also attend the Structure-Based Drug Design conference,
you can save up to $350 if you register by
Friday, March 11.



James Prudhomme

Cambridge Healthtech Institute

250 First Avenue, Suite 300

Needham, MA 02494

Phone: 781-972-5400

Fax: 781-972-5425




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