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Dear Subscriber,
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UniProt Release 12 Note
24-Jul-2007
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CONTENTS
1. Introduction
2. Database description
3. Current release contents
4. Description of changes made to UniProt since release 11.0
5. Forthcoming changes
6. How to link to UniProt
7. Feedback
8. Acknowledgements
9. Terms of use
10. Citation
11. Contact
1. INTRODUCTION
The UniProt Consortium--European Bioinformatics Institute (EBI), Swiss
Institute of Bioinformatics (SIB) and Protein Information Resource
(PIR)--is pleased to announce UniProt Release 12 (24-Jul-2007). UniProt
is updated bi-weekly, and can be accessed online for searches or
download at http://www.uniprot.org.
2. DATABASE DESCRIPTION
The Universal Protein Resource (UniProt), a collaboration between the
European Bioinformatics Institute (EBI), the Swiss Institute of
Bioinformatics (SIB), and the Protein Information Resource (PIR), is
comprised of four databases, each optimized for different uses. The
UniProt Knowledgebase (UniProtKB) is the central access point for
extensively curated protein information, including function,
classification and cross-references. The UniProt Reference Clusters
(UniRef) combine closely related sequences into a single record to speed
up sequence similarity searches. The UniProt Archive (UniParc) is a
comprehensive repository of all protein sequences, consisting only of
unique identifiers and
sequences. The UniProt Metagenomic and Environmental Sequences (UniMES)
database is a repository specifically developed for metagenomic and
environmental data. Additional information on UniProt is available at
ftp://ftp.uniprot.org/pub/databases/uniprot/README and in the UniProt
Knowledgebase user manual (http://expasy.org/sprot/userman.html).
3. CURRENT RELEASE CONTENTS
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UniProt Release 12
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Database -- Entries
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UniProtKB -- 4,949,164 entries (UniProtKB/Swiss-Prot section: 276,256;
UniProtKB/TrEMBL section: 4,672,908)
UniRef100 -- 4,910,948
UniRef90 -- 3,145,989
UniRef50 -- 1,555,946
UniParc -- 15,345,639
UniMES -- 6,028,191
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Detailed release statistics for UniProtKB/Swiss-Prot and
UniProtKB/TrEMBL sections of the UniProt Knowledgebase can be viewed at
http://www.expasy.org/sprot/relnotes/relstat.html and
http://www.ebi.ac.uk/swissprot/sptr_stats/index.html, respectively.
4. DESCRIPTION OF CHANGES MADE TO UNIPROT SINCE RELEASE 11.0
UniProt Knowledgebase - To learn about the changes since the last major
release please read the UniProtKB/Swiss-Prot and UniProtKB/TrEMBL
release notes (http://expasy.org/sprot/relnotes/) and the recent changes
document (http://expasy.org/sprot/relnotes/sp_news.html).
5. FORTHCOMING CHANGES
Forthcoming changes concerning the UniProt Knowledgebase are described
in http://expasy.org/sprot/relnotes/sp_soon.html.
6. HOW TO LINK TO UNIPROT ENTRIES
How to link to UniProt entries can be found at
http://www.uniprot.org/support/docs/linkUniProt.html
7. FEEDBACK
We are constantly trying to improve our database in terms of accuracy
and representation and hence, consider your feedback extremely valuable.
Please contact us if you have any questions
(http://www.uniprot.org/support/helpdesk.shtml) or comments
(http://www.uniprot.org/support/feedback.shtml). You can also subscribe
to e-mail alerts (http://www.uniprot.org/support/alerts.shtml) for the
latest information on UniProt databases.
Submit new sequence data, updates and corrections at
http://www.uniprot.org/support/submissions.shtml
8. ACKNOWLEDGEMENTS
UniProt is mainly supported by the National Institutes of Health (NIH)
grant 1 U01 HG02712-01. Additional support for the EBI's involvement in
UniProt comes from the European Commission (EC)'s FELICS grant
(021902RII3) and from the NIH grant 1R01HGO2273-01. UniProtKB/Swiss-Prot
activities at the SIB are supported by the Swiss Federal Government
through the Federal Office of Education and Science. PIR activities are
also supported by the NIH grants for NIAID proteomic resource
(HHSN266200400061C) and grid enablement (NCI-caBIGICR-10-10-01) and
BioThesaurus (ITR-0205470).
9. TERMS OF USE
UniProt is available for both commercial and non-commercial use. Please
see http://www.uniprot.org/terms for details.
10. CITATION
If you want to cite UniProt in a publication please use the following
reference:
The UniProt Consortium. The Universal Protein Resource (UniProt).
Nucleic Acids Res. 2007 Jan;35(Database issue):D193-7.
11. CONTACT
EMBL Outstation
European Bioinformatics Institute (EBI)
Wellcome Trust Genome Campus
Hinxton
Cambridge CB10 1SD
United Kingdom
Telephone: (+44 1223) 494 444
Fax: (+44 1223) 494 468
Electronic mail address: datalib from ebi.ac.uk / swissprot from ebi.ac.uk
WWW server: http://www.ebi.ac.uk/
Swiss Institute of Bioinformatics (SIB)
Centre Medical Universitaire
1, rue Michel Servet
1211 Geneva 4
Switzerland
Telephone: (+41 22) 702 50 50
Fax: (+41 22) 702 58 58
Electronic mail address: swiss-prot from expasy.org
WWW server: http://www.expasy.org/
Protein Information Resource (PIR)
Georgetown University Medical Center
3300 Whitehaven Street NW
Suite 1200
Washington, DC 20007
United States of America
Telephone: (+1 202) 687 1039
Fax: (+1 202) 687 0057
Electronic mail address: pirmail from georgetown.edu
WWW server: http://pir.georgetown.edu
Sincerely,
UniProt Help Desk
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