CALL-FOR-PAPERS: Haplotypes, Linkage Disequilibrium, & Populations. Jan 3-7, 2003, Kauai, Hawaii

Francisco De La Vega delavefm at appliedbiosystems.com
Fri May 10 09:01:51 EST 2002

Human Genomic Variation: Haplotypes, Linkage Disequilibirum, and
January 3-7, 2003
Island of Kauai, Hawaii, USA

A session of the Pacific Symposium on Biocomputing 2003

The post-genomic research in human and population genetics is
centering around the study of the patterns of genetic variation
across the genome and among populations with the aim of
understanding the origin of complex disease and the evolutionary
history of our species. Recently, a major initiative to develop
the so-called Haplotype Map of the Human Genome has been
enacted. Its rationale is that this information will make it
possible to conduct disease gene association studies more
quickly and efficiently than ever before, resulting in the more
rapid elucidation of the variants that predispose to disease and
influence drug response.

With the imminent flood of data from the Haplotype Map project,
there is an urgent need to extend haplotype-related
computational methods to the whole-genome scale. There are many
fundamental computational and statistical problems to solve: how
to calculate genome-wide haplotypes and determine haplotype
block boundaries on sequence, how to find the optimal number of
SNPs per haplotype block, how to account for the variation in LD
across different populations, how to find the most informative
SNPs for each haplotype block, how to deal with uncertainty in
annotations and map locations, development of controls for
spurious statistical association, the effects of population
substructure, estimation of statistical significance, effects of
genotyping error, how to manage and represent the large amount
of data, methods for modeling the genotyping process in silico
to avoid artifacts and failures in the massive genotyping
projects, etc. Finally, methodologies to use the haplotype
information for more efficient design and analysis of whole-
genome association studies are in their infancy and deserve

The session of PSB 2003 "Human Genome Variation: Haplotypes,
Linkage Disequilibrium, and Populations" will be devoted to the
tools needed to analyze the upcoming deluge of genotyping
information, encouraging the presentation and discussion of new
research, methods, algorithms, and tools, that promises to
facilitate the elucidation of the connections between genotypes
and phenotypes using the data generated by high-throughput SNP
genotyping technologies.


We encourage academic, industrial and government scientists to
submit manuscripts with original work in the subject area. PSB
will publish accepted full papers in an archival proceedings
indexed in Medline. All contributed papers will be rigorously
peer-reviewed by at least three referees. A limited number of
papers will be selected for oral presentation to the full
assembled conference. Posters and computer demonstrations are
also requested to complement the session, and require the
submission of a one-page abstract. Accepted poster abstracts
will be distributed at the conference separately from the
archival Proceedings. In addition of the oral presentation of
the full papers, and the poster session, an invited panel
discussion devised to encourage exchange between industry and
academic scientists will be also held.


Strategies for SNP selection as markers for whole-genome
association studies across different populations.
Theoretical and statistical frameworks for the construction
of haplotype maps, and their variability across
Algorithms for haplotype inference, construction of linkage
disequilibrium maps, haplotype tagging, and optimization of
SNP marker sets.
Methods for analyzing association, linkage disequilibrium,
and QTL using SNPs in candidate gene sets and whole genome
Ontologies, control vocabularies, and data models for
genotypic, haplotype, and phenotypic databases.
Visualization and analysis of large-scale genotypic-
haplotypic data.
Evolutionary models of genome variability and linkage
disequilibrium vs. empirical data findings.
Data management and quality control methods for the high-
throughput genotyping laboratory

Deadline for paper submission:        			July 15, 2002
Author notification:                     			September
6, 2002
Deadline for poster abstracts:     			November 1,


The Pacific Symposium on Biocomputing (PSB 2003) is an
international, multidisciplinary conference for the presentation
and discussion of current research in the theory and application
of computational methods in problems of biological significance.
The symposium is a forum for the presentation of work in
databases, algorithms, interfaces, visualization, modeling and
other computational methods, as applied to the data-rich areas
of molecular biology. PSB 2003 will be held January 3-7, 2003,
in Lihue, Kauai at the Kauai Marriott Resort and Beach Club.

For more information about this session and the whole conference
see the official web site at: http://PSB.Stanford.edu

Francisco M. De La Vega
Applied Biosystems
Foster City, CA, USA
E-mail:delavefm@ appliedbiosystems.com (Main Contact)

Kenneth K. Kidd
Yale University School of Medicine
New Haven, CT, USA
Kenneth.Kidd@ yale.edu

Isaac S. Kohane
Children's Hospital of Boston and Harvard Medical School,
Cambridge, MA, USA.
E-mail: isaac_kohane@ harvard.edu

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