New Release of ROSE - Random-model Of Sequence Evolution
We are pleased to announce that release 1.2 of Rose is now available
on the Bielefeld Bioinformatics Server. Rose implements probabilistic
models of RNA, DNA, and protein sequence evolution via insertions,
deletions and substitutions. The source code is published under the
GPL.
New Features:
- Standard DNA evolution models (JC, HKY, F81, F84, K2P)
- multiple runs, single invocation
- FASTA or PHYLIP output formats
Rose Copyright (c) 1997-2001 University of Bielefeld, Germany and
Deutsches Krebsforschungszentrum (DKFZ) Heidelberg, Germany.
Rose 1.2 Website
http://bibiserv.TechFak.Uni-Bielefeld.DE/rose/
Rose 1.2 Download
http://BiBiServ.TechFak.Uni-Bielefeld.DE/
cgi-bin/bibi_download?tool=rose&version=1.2
Authors
Jens Stoye (1), Dirk Evers (2), Folker Meyer (3)
(1) Max Planck Institute (MPI) for Molecular Genetics, Computational
Molecular Biology, Berlin, Germany; (2) Faculty of Technology,
University of Bielefeld, Germany; (3) Center for Genome Research,
University of Bielefeld, Germany
About Rose:
Guided by an evolutionary tree, a family of related sequences is
created from a common ancestor sequence by insertion, deletion and
substitution of characters. During this artificial evolutionary
process, the `true' history is logged and the `correct' multiple
sequence alignment is created simultaneously. The model also allows
for varying rates of mutation within the sequences, making it possible
to establish so-called sequence motifs. The data created by Rose are
suitable for the evaluation of methods in multiple sequence alignment
computation and the prediction of phylogenetic relationships. It can
also be useful when teaching courses in or developing models of
sequence evolution and in the study of evolutionary processes.
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Jens Stoye phone: +49-30-8413-1352
Max Planck Institute for Molecular Genetics fax: +49-30-8413-1152
Computational Molecular Biology
Ihnestr. 73
14195 Berlin stoye at molgen.mpg.de
Germany http://www.dkfz.de/tbi/people/stoye/
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