Why not try DNATools?
This program includes nearly all trivial functions for dna and protein
analysis and can be used free of charge (but then requires registration
every four months. A full license is US$100).
The program supports clustalw and x, blast mail, blast client and formatdb
and connects directly to GeneDoc. Contains facilities for direct mail
ordering and management of primers. Also includes a full set of functions
for EST project management and for SAGE analysis plus a lot more...
Visit the dnatools homepage for more information:
Soeren W. Rasmussen
swr at crc.dk