ClustalW: number of sequences

Kevin Karplus karplus at cse.ucsc.edu
Sat Feb 26 08:50:08 EST 2000

If you have several thousand sequences to align, you might want to use
the SAM HMM software:

I often align 10,000 protein sequences using the program, without
memory problems.  

I believe SAM has also been used to do rough alignments of 1000s of
1000-long RNA sequences, though HMMs are not good for aligning
structural RNA, as they can't see the important base-pairing signals.

Kevin Karplus 	karplus at cse.ucsc.edu	http://www.cse.ucsc.edu/~karplus
life member (LAB, Adventure Cycling, American Youth Hostels)
Effective Cycling Instructor #218-ck
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