DIALIGN 2 available
We would like to announce a new release of the multiple
alignment program DIALIGN.
DIALIGN relies on comparing whole segments of the sequences
instead of comparing single residues. Pairwise as well as
multiple alignments are constructed from gapfree pairs of
segments (so-called `diagonals').
DIALIGN does not use any gap penalty, thus avoiding this
critical parameter. Consequently, the program is able to
detect isolated local homologies that can not be detected
by standard multiple alignment methods.
An online version of the program is available at the
Bielefeld University Bioinformatics Server (BiBiServ)
without previous limitations, i.e. large data sets can be
aligned and DNA as well as protein sequence alignment is
In addition, executables for various platforms are available at
If you have any problems, questions, or comments concerning
DIALIGN, please let us know!
P.S. Special thanks to Ashok Aiyar for all his help!
Dr. Burkhard Morgenstern
GSF - National Research Center for Environment and Health
Institute of Biomathematics and Biometry
Ingolstaedter Landstr. 1
email: morgenst at gsf.de