ORPHEUS: bacterial gene prediction

Dmitrij Frishman frishman at mips.biochem.mpg.de
Tue May 12 06:13:00 EST 1998

We are pleased to announce the availability of a new bacterial gene
prediction program ORPHEUS:


ORPHEUS is a software system for gene prediction in complete bacterial
genomes and large genomic fragments. The analysis starts with database
similarity search and identification of reliable gene fragments. The
latter are used to derive statistical characteristics of protein-coding
regions and ribosome-binding sites. At the final step, the complete set
of genes in the analyzed genome is predicted, with special attention
paid to correct gene start identification. All analysis steps are fully

Detailed description of ORPHEUS has been published in the following

Frishman, D. (*), Mironov, A. (**), Mewes, H.-W. (*), and Gelfand,
(1998). Combining diverse evidence for gene recognition in completely
sequenced bacterial genomes. Nucl. Acids Res., in press. 

(*)   Munich Information Center for Protein Sequences (MIPS) of the
      National Center for Health and Environment (GSF), Am Klopferspitz
      18a, 82152 Martinsried, Germany
(**)  Laboratory of Mathematical Methods, National Center for
      Information NIIGENETIKA, Moscow, 113545, Russia
(***) Institute of Protein Research, Russian Academy of Sciences,
      142292, Russia.

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