Translation of protein sequence to nucleotide sequence

Michele Clamp michele at speed.ebi.ac.uk
Tue Aug 11 06:34:28 EST 1998

mcbaet at MCBSGS1.IMCB.NUS.EDU.SG (Anthony Ting) writes:

> Hi there,
>     Is anyone aware of a program that translate a protein sequence into
> a nucleotide sequence given a specific codon usage table?

The only thing I can think of is GCG's backtranslate which will give
you the most and least probable DNA sequence.

On a similar note and while I'm thinking of it does anyone out there
know of something that will compare 2 protein sequences at the DNA
level and give you the most likely DNA alignment.  I'd find this
useful for finding possible undetected frame shift errors in multiple

Thinking about it this is trickier than I first imagined and not just 
a quick perl hack. 


Dr Michele Clamp ,        EMBL-European Bioinformatics Institute 
Hinxton, Cambs CB10 1SD,  email : michele at ebi.ac.uk
UK                        Tel:  01223 494682    Fax: 01223 494468

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