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PUBLIC DOMAIN PROGRAM DYNAFIT AVAILABLE
DynaFit is a program for simulation and least-squares
fitting of biochemical kinetic data. The user enters
the reaction mechanism symbolically, such as this:
; "Slow, tight" inhibition of HIV proteinase
[mechanism]
E + S <==> ES : k ks
ES ---> E + P : kr
E + I <==> EI : k1 k2
EI <==> EJ : k3 k4
The machine then derives the underlying system of
differential equations (to compute the time-course of
the reaction) or algebraic equations (to compute the
composision at equilibrium).
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TEST PROBLEMS
The program should be downloaded along with a set of
test examples, all of them based on real experimental
mostly from biochemical kinetics, but the same methods
can be used for other areas of chemistry and biology.
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REVIEWS
A reviewer had this to say about DynaFit: "If you do any
kind of kinetic data analysis as part of your research
program, be sure to download DynaFit from the BioKin Web
site." (HMS Beagle Newsletter "Software Alert", volume
1997 No. 9).
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LINKS
http://www.biokin.com/ BioKin home
http://www.biokin.com/dynafit/index.shtml ... DynaFit
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REFERENCES
P. Kuzmic (1996) Anal. Biochem. 237, 260-273.
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Petr Kuzmic Ph.D. * BioKin Ltd. * Madison, WI 53708-8336, USA
pkuzmic at biokin.com * http://www.biokin.com * 608.256.1269 fax
