GenoCheck, version 1.0
Meg Gelder Ehm
Rice University
Department of Statistics
Houston, Texas USA
gelder at stat.rice.edu
New error detection capabilities are available for genetic linkage data!
GenoCheck, 1.0 is an error checking program designed to identify
individuals and loci that are likely to contain errors. The statistical
method was designed to identify typing error, but is general enough to
pinpoint any unlikely genotype still consistent with Mendelian inheritance.
GenoCheck was developed using FASTLINK 2.2 (modified version of LINKAGE 5.1)
and uses a similar file configuration and installation procedure. The code
contains checkpointing facilities that allow users to recover from crashes
without having to rerun the program and comes with documentation.
For more information about the code or the algorithm visit me at the American
Society of Human Genetics meeting. I will be at my poster 1094 from 4-6pm on
Thursday, October 26.
The instructions for retrieving the code are given below:
ftp softlib.cs.rice.edu
Login as anonymous and leave your full e-mail address as the password.
cd pub/GenoCheck
In that directory you will find various files. You can get everything at
once by retrieving:
genocheck.tar.Z
and then (outside of ftp) doing the commands:
uncompress genocheck.tar.Z
tar xvf genocheck.tar
If you prefer to get the files piecemeal, instead of getting genocheck.tar.Z
start by getting README*. The file README (with no extension) will describe
all of the documentation.
The statistical algorithm implemented in GenoCheck, version 1.0
is described in the papers:
M. G. Ehm, R.W. Cottingham Jr., and M. Kimmel. Error Detection
in Genetic Linkage Data Using Likelihood Based Methods. Journal
of Biological Systems, Vol. 3, No. 1 (1995) 13-25.
M. G. Ehm, R. W. Cottingham Jr., and M. Kimmel. Error Detection
in Genetic Linkage Data Using Likelihood Based Methods. American
Journal of Human Genetics, Vol. 58, No. 1 (1996) (to appear).
Please e-mail any questions or suggestions about GenoCheck to
gelder at stat.rice.edu.
Thanks,
