Version 2.0 of GAS is now available. The initial distribution is via WWW
from address:
http://info.ox.ac.uk/~ayoung/gas.html
It can also be obtained by anonymous FTP from
ftp.ox.ac.uk pub/users/ayoung
GAS is currently compiled for the following machines/operating systems
* IBM PC/MSDOS * Sun/Solaris * DEC Alpha/OSF
* Silicon Graphics/IRIX * DEC Vax/VMS * Sun/SunOS
* DEC Alpha/VMS * IBM RS6000/AIX * DEC Ultrix
Other platforms possible by arrangement.
Each version comes with a complete. Comprehensive manuals and many example
and demonstration files are available with the package.
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Amongst the main improvements to the previous public release (1.4) are:
* Expanded manuals with more examples
* Direct graphical output of results using Postscript (use `set psfile')
* Sib-pair IBD interval mapping for quantitative traits - sibihe();
* Locus ordering option (tested upto 250 loci simultaneously) - sibmap();
* 2-point lodscores calculations - lik2point();
* Ability to `repair' pedigrees by deducing some missing genotypes
* Sib-pair IBD interval mapping for categorical traits - sibides();
* Lodscore maps with maximization and exclusion options - likmap();
* Lange's Z statistic for IBS sib-pair analysis - sibstate();
* Option to test association of allele presence/absence - assmwu();
* Improved inheritance checking of data
* 2-locus IBD MLS routine - sib2mls();
* Haplotype frequency analysis for children - hapchild();
* Inter-group association comparison test - asscompare();
* Extended sib-pair test for analyzing half-siblings - sibdes();
* Improved algorithms for global `alsize' binning
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The lodscore routines lik2point() and likmap() utilize a beta version of the
`Vitesse' likelihood engine devised by Jeff O'Connell. This is a very cool
program capable of fast simultaneous 8-point lodscores with highly polymorphic
markers.
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* the sib*reg(); routines have been superceded by sibhe(); and sibihe();
* sibqmwu()/sibdmls() have been enhanced and renamed to sibmwu()/sibmls();
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Two bugs (in 1.4) were found and exterminated during the upgrade:
[] assgenorr : miscount in some allele frequencies, so that relative risks
were incorrect by (upto) a factor of 2.
[] dissect locus : for QTL distribution of subjects across normalized parameter
range, the scale was shrunk so that all the subjects fitted into the first 9/10
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/ \ / | / Alan Young @ uk.ac.ox.vax
/____/ / ___ __ |___/
/ / / / | / | / "The bigger they are,
/ \_/\__\__/|_/ /_________/ the harder they fall on you."
