INTERNET ROCKHOUSE hquinn at shellx.best.com
Sat Nov 25 17:19:44 EST 1995

: >Dear colleagues,
: >is there any programm available for the generation of restriction sites in
: >a given nucleotide sequence? I have to introduce several restriction sites
: >in a nucleotide sequence by changing the codon usage without altering 
: >the amino acid sequence. Introducing these sites by hand is a very tediuos 
: >work. So, I would like to know if someone knows a computer program doing 
: >this work.

: If you have access to GCG, the mapping programs have a "/silent" option 
: (-silent on Unix) which will do exactly that, find silent restriction sites.

Didn't realize that GCG has this function; I was looking for the same thing. 
The program 'mutsite' is part of the pc-gene software suite and does 
precisely this.

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