bochet at bobby.iaf.cnrs-gif.fr bochet at bobby.iaf.cnrs-gif.fr
Fri Nov 24 10:57:46 EST 1995

 In article <48sku3$815 at mserv1.dl.ac.uk>,
    jpleiss at TEBIO1.BIOLOGIE.UNI-STUTTGART.DE (Juergen Pleiss) wrote:
>Dear colleagues,
>is there any programm available for the generation of restriction sites in
>a given nucleotide sequence? I have to introduce several restriction sites
>in a nucleotide sequence by changing the codon usage without altering 
>the amino acid sequence. Introducing these sites by hand is a very tediuos 
>work. So, I would like to know if someone knows a computer program doing 
>this work.

If you have access to GCG, the mapping programs have a "/silent" option 
(-silent on Unix) which will do exactly that, find silent restriction sites.
         Pascal  Bochet      | internet: bochet at bobby.iaf.cnrs-gif.fr
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